微生物代谢产物调整杏仁体神经元过敏和与焦虑相关的行为
Weonjin Yu1, Yixin Xiao1, Anusha Jayaraman2
1Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.
EMBO molecular medicine
|February 5, 2025
概括
肠道微生物影响焦虑. 微生物代谢物,如内,改变大脑电路,特别是在底侧桃体 (BLA),通过恢复神经元功能来减少小鼠的焦虑行为.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 行为科学 行为科学
背景情况:
- 肠道微生物组成的变化与动物的焦虑相关行为有关.
- 连接肠道微生物及其代谢物与焦虑的特定神经通路仍然不清楚.
研究的目的:
- 调查肠道微生物群与焦虑行为之间的联系背后的神经电路.
- 确定微生物及其代谢物影响焦虑的分子机制.
主要方法:
- 利用无细菌 (GF) 的小鼠来评估与焦虑相关的行为和神经活动.
- 在基底侧桃体 (BLA) 中测量了即时早期基因表达 (c-Fos).
- 在电生理学上检查了BLA金字塔神经元刺激性和突触活性,重点关注小导电性激活 (SK) 通道.
主要成果:
- GF小鼠表现出与焦虑相关的行为增加和BLA中的c-Fos表达升高.
- 这些变化与BLA金字塔神经元中神经元刺激性和突触活性增加相关,这是由于SK通道电流减少.
- 微生物殖民或使用微生物衍生的内醇使SK通道活动正常化并减少焦虑行为.
结论:
- 肠道微生物及其代谢物,如内醇,直接调节BLA神经元的功能性质.
- 这种在BLA中神经元功能的微生物调节提供了一个将肠道微生物群与焦虑联系起来的分子机制.
- 这些发现表明,微生物对焦虑的调节与进化保存的防御机制之间存在联系.
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