对外科手术期间的真菌预防方案的评估 在正确体肝移植中发生的变化
Megan M Singlar1,2, Xhilda Xhemali1, Kyle D Brizendine3
1Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
The Annals of pharmacotherapy
|February 5, 2025
概括
一项针对肝移植患者的新抗真菌预防方案,改善了肝移植患者的坚持率,达到84%,并且数量减少了侵入性真菌感染 (IFI). 这种有针对性的方法提高了移植后抗真菌护理的一致性.
科学领域:
- 移植手术 移植手术
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 正位肝移植 (OLT) 患者面临着侵入性真菌感染 (IFI) 的重大风险.
- 目前针对OLT接受者的抗真菌预防方案需要改进,以优化风险因素识别和治疗策略.
研究的目的:
- 评估OLT后实施的针对性抗真菌预防方案对IFI率的影响.
- 评估OLT患者遵守抗真菌预防方案的情况.
主要方法:
- 一项回顾性观察队列研究比较了OLT患者在 (n=134) 和 (n=166) 协议实施之前.
- 主要终点:在术后第0天 (POD0) 坚持预防.
- 二级终点:已证实或可能发生的IFI后OLT的90天发病率.
主要成果:
- 在预防期间,协议的遵守率达到84%,高于POD0.0的66%.
- 侵袭性真菌感染 (IFI) 率从协议前的6.7%下降到协议后的3.6%.
- IFI的中位时间从协议前的8天增加到协议后的15天.
结论:
- 一个针对性的OLT后抗真菌预防方案提高了抗真菌处方的一致性.
- 该研究表明,IFI率的高度坚持和数值降低表明了协议的有效性.
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