甘油-葡萄糖指数和Helicobacter pylori感染患者的死亡风险:一项国家队列研究
Yue Cao1, Lingxiao Li1, Feipeng Qiu1
1Department of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan City, Guangdong, 528308, China.
BMC infectious diseases
|February 5, 2025
概括
较高的甘油三糖指数 (TyG) 水平与Helicobacter pylori (H. pylori) 感染患者的死亡率增加有关. 这项研究发现,Tyg指数升高与全因和心血管死亡风险更高之间存在显著的关联.
科学领域:
- 心血管健康 心血管健康
- 代谢综合征是代谢综合征的一种.
- 传染性疾病 传染性疾病
背景情况:
- 杆菌 (H. pylori) 感染与胰岛素耐药性和死亡率增加有关.
- 对H. pylori感染个体的特定胰岛素抵抗指数和结果的研究是有限的.
研究的目的:
- 调查胰岛素抵抗的标志物甘油三糖指数 (TyG) 与H. pylori感染患者的死亡率之间的关联.
- 检查TyG指数与所有原因和心血管死亡率之间的关系.
主要方法:
- 来自NHANES 1999-2000年队列的数据分析.
- 使用加权的考克斯比例危险模型和受限立方线分析.
- 在感染H. pylori的参与者中评估死亡结果.
主要成果:
- 总共有627名参与者被分析,随访时间中位数为20.8年.
- 较高的TyG指数与所有原因死亡率 (HR 1.70) 和心血管死亡率 (HR 2.90) 的增加显著相关.
- 在大多数子组中观察到TyG指数和死亡风险之间的线性关系.
结论:
- 甘油三糖 (TyG) 指数是H. pylori感染患者死亡率的重要预测指标.
- 提升的TyG指数与所有原因和心血管死亡的风险增加密切相关.
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