捷克共和国的HPV诱导疾病负担和追赶疫苗接种的成本效益:基于模型的研究
Vojtech Kamenský1, Lukáš Dostálek2, Martin Rožánek1
1Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, nám. Sítná 3105, Prague, 272 01, Czech Republic.
BMC public health
|February 5, 2025
概括
为15-21岁的人实施人类乳头瘤病毒 (HPV) 追赶疫苗接种计划是具有成本效益的. 这一策略显著预防了与HPV相关的癌症,并改善了男性和女性的质量调整寿命 (QALYs).
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 卫生经济学 卫生经济学
背景情况:
- 人类乳头瘤病毒 (HPV) 感染是常见的性传播感染,与各种癌症有关.
- 了解HPV相关疾病的健康和经济负担对于公共卫生政策至关重要.
- 评估有针对性的干预措施,如追赶疫苗接种计划,对于预防疾病至关重要.
研究的目的:
- 分析捷克共和国HPV相关疾病对健康和经济的影响.
- 评估人类乳头瘤病毒 (HPV) 追赶疫苗接种计划对15至21岁的人的成本效益.
- 量化疫苗接种在质量调整寿命年 (QALYs) 和癌症预防方面的潜在益处.
主要方法:
- 使用马尔科夫多态模型来模拟与HPV感染相关的终身健康结果和成本.
- 模拟了15至21岁的个人队列,以评估追赶疫苗接种策略的影响.
- 进行了概率敏感性分析,以评估研究结果的可靠性.
主要成果:
- 追赶疫苗接种显著增加了女性 (122,246) 和男性 (200,852) 队列的总质量调整寿命年 (QALYs).
- 接种疫苗的策略预防了男女癌症相关的329例死亡.
- 在99.3%的女性代和80.3%的男性代中,疫苗接种被确定为主导策略,男性的增量成本效益比 (ICER) 低于42,000 CZK/QALY.
结论:
- 针对15-21岁的追赶疫苗接种计划是捷克共和国的成本效益战略.
- 这种干预措施显示出预防HPV相关癌症和改善人口健康结果的巨大潜力.
- 这些发现支持实施追赶HPV疫苗接种,以减少HPV相关疾病的负担.
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