相关实验视频

Updated: May 29, 2025

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

Published on: June 8, 2016

通过超分子相互作用驱动的聚合,为海水浸泡的伤口制备脂酸生物粘合剂

Rui Lei¹, Wenjun Wang¹, Guan Li¹

¹Department of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, P. R. China.

Journal of nanobiotechnology

|February 5, 2025

概括

这项研究提出了基于α-酸 (LA) 的新型生物粘合剂,用于治疗海水浸泡的伤口. 这些先进的伤口带提供强大的水下粘附力,通过调节pH值并提供抗炎和抗菌作用来促进愈合.

科学领域:

生物材料科学生物材料科学
伤口愈合治愈伤口愈合
材料化学材料化学

背景情况:

浸入海水的伤口面临着高pH值和感染等挑战,可能导致慢性疾病.
对海上创伤的有效紧急治疗需要先进的伤口护理解决方案.
现有的治疗方法可能无法充分解决海水浸入伤口的独特微观环境.

研究的目的:

开发用于海上创伤的快速准备,室温生物粘合剂,具有强大的水下粘合力.
创造生物粘合剂,可以稳定伤口的微环境并促进愈合.
为了利用超分子相互作用增强生物粘合性质.

主要方法:

生物粘合剂的制造是通过超分子相互作用的α-酸 (LA),MXene和Ag+的聚合.
整合MXene/Ag+/LA相互作用到聚二乙基甲酸 (pHEMA) 电中以提高粘合力.
生物粘合性质的表征,包括粘合强度,pH响应度和抗炎/抗菌作用.

主要成果:

快速制备的生物粘合剂表现出强大的接口粘附和机械自强化特性.
电膜可以达到高达2MPa的粘合强度.
生物粘合剂有效调整了伤口的pH值,释放了抗炎性LA,并表现出抗菌活性.

结论:

开发的基于LA的生物粘合剂为浸入海水的伤口的紧急治疗提供了有希望的解决方案.
这些生物粘合剂提供稳定的屏障保护,纠正不良的伤口微环境,促进愈合.
超分子聚合策略使高性能水下生物粘合剂的高效制造成为可能.

关键词:

生物粘合剂生物粘合剂脂酸酸是什么意思脂酸是什么意思这就是MXene MXene.在海水中浸泡的伤口.超分子相互作用

更多相关视频

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering

Published on: March 17, 2023

相关概念视频

Colloids

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...

Noncovalent Attractions in Biomolecules

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...

Cohesion

Cohesion

Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature.
On a...