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疹病毒对慢性外周病变中的前炎性细胞因子的影响

Jelena Popović¹, Tatjana Cvetković², Tanja Džopalić³

¹Department of Restorative Dentistry and Endodontics, Clinic of Dental Medicine, Faculty of Medicine, University of Niš, Niš, Serbia.

Medical science monitor : international medical journal of experimental and clinical research

|February 6, 2025

概括

像细胞巨乳病毒 (CMV) 和爱斯坦-巴尔病毒 (EBV) 这样的疹病毒在症状的牙周炎中更常见. 这些病毒感染与较高水平的炎症性细胞因子IL-6,IL-8和TNF-alpha相关.

科学领域:

口腔病理学口腔病理学
传染病传染病传染病
免疫学免疫学免疫学

背景情况:

牙周膜炎是一种牙纸的感染,可以损害牙周细胞周围的组织.
这种情况可能与牙损或创伤有关.
疹病毒与各种炎症状况有关.

研究的目的:

在周围病变中调查人类细胞巨化病毒 (HCMV) 和爱斯坦-巴尔病毒 (EBV) 的存在.
量化关键炎症性细胞因子与病毒存在相关的水平.
为了将病毒感染与牙周顶部牙周炎的症状状况相关联.

主要方法:

聚合酶链反应 (PCR) 用于检测HCMV和EBVDNA.
与酶相关的免疫吸收试验 (ELISA) 用于测量干白素-6 (IL-6),干白素-8 (IL-8),瘤坏死因子-α (TNF-α) 和转化生长因子β-1 (TGF-β1).
79名患者的周围病变被分类为有症状或无症状.

主要成果:

在症状性病变中,HCMV和双重HCMV/EBV感染的发生率明显高.
与病毒阴性病变相比,病毒阳性病变的IL-6,IL-8和TNF-alpha度显著更高.
在双重感染中观察到TGF-β1水平升高,但在所有病毒阳性病例中不一致.

结论:

疹病毒在症状性病变中增加的患病率表明,疹病毒在疾病发病过程中起着重要作用.
增加TNF-alpha,IL-6和IL-8的表达与疹病毒感染和临床表现有关.
TGF-β1似乎不是与疹病毒相关的周周病变的重要因素.

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