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深度学习增强化学发光垂直流量检测高灵敏性心脏热素I测试

Gyeo-Re Han¹, Artem Goncharov¹, Merve Eryilmaz^1,2

¹Electrical & Computer Engineering Department, University of California, Los Angeles, CA, 90095, USA.

Small (Weinheim an der Bergstrasse, Germany)

|February 6, 2025

概括

一种新的化学发光垂直流量测定 (CL-VFA) 民主化了心脏素I (cTnI) 测试. 这一创新系统提供了实验室级的灵敏度,用于在护理地点快速诊断心肌梗塞.

科学领域:

生物医学工程生物医学工程
分析化学分析化学
医学诊断医学诊断医学诊断

背景情况:

临床检测 (POCT) 需要敏感而精确的生物标志物检测.
心脏素I (cTnI) 是诊断心肌梗塞的一个关键生物标志物.
当前的POCT方法往往缺乏实验室级测试的灵敏度.

研究的目的:

开发一种高灵敏度的化学发光垂直流测定 (CL-VFA) 用于检测心脏素I (cTnI).
整合先进的传感,成像和深度学习,以准确量化生物标志物.
为了在各种医疗保健环境中实现可访问和快速的心脏生物标志物测试.

主要方法:

开发一种基于聚合酶的聚合基联的化学发光纸张传感器.
使用一个便携式的,高性能化学发光读取器.
使用神经网络算法从试验数据中推断cTnI度.

主要成果:

该CL-VFA的检测极限达到0.16 pg mL-1的检测极限,变化系数<15%.
测试表明,使用50μL血清,在六个数量级的范围内具有广泛的动态范围.
结果与盲人患者样本验证中的临床级分析仪有很强的相关性.

结论:

与传统分析仪相比,CL-VFA系统在灵敏度上提供了数量级的改进.
这项技术能够快速,低成本,准确地量化CTnI,用于心脏评估.
在缺乏服务的地区,CL-VFA具有改善紧急护理和医疗保健准入的巨大潜力.

关键词:

化学发光的光泽通过深度学习启用传感传感.高灵敏度的托罗邦尼.医疗服务中心的检测.垂直流量测试试验垂直流量测试

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