打,体重指数和冠状动脉疾病之间的关联:亚洲的观察性和孟德尔随机化研究
Yunqing Zhu1, Yongbing Lan1, Jun Lv1,2,3
1Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.
概括
在东亚人中,习惯性打增加了冠状动脉疾病 (CAD),心肌梗塞 (MI) 和稳定性胸痛 (SAP) 的风险. 这些风险与体重指数 (BMI) 无关,这表明打干预措施可以降低CAD率.
科学领域:
- 心血管流行病学心血管流行病学
- 遗传学 是一个遗传学.
- 睡眠医学 睡眠医学
背景情况:
- 观察性研究表明,打和冠状动脉疾病 (CAD) 之间存在复杂的联系.
- 打对CAD的独立影响,特别是在东亚人群中,需要进一步研究.
- 身体质量指数 (BMI) 在打-CAD关系中的作用尚未完全理解.
研究的目的:
- 在东亚成年人中调查打和CAD之间的因果关系.
- 为了确定打和CAD之间的关系是否独立于BMI.
- 探索习惯性打对不同类型的CAD的影响,包括心肌梗塞 (MI) 和稳定性胸痛 (SAP).
主要方法:
- 来自中国Kadoorie生物库 (CKB) 的497,250名成年人的前性分析,使用多变量Cox回归.
- 全基因组关联 (GWAS) 总结统计数据对打和BMI从CKB.
- 使用CKB和日本生物银行 (BBJ) 的GWAS数据进行两样双向门德尔随机化 (MR) 分析.
主要成果:
- 习惯性打显著与发生CAD,MI和SAP的风险增加有关.
- 基因预测的习惯性打显示出与CAD和MI的因果关系.
- 即使调整了BMI,这些关联仍然存在,这表明习惯性打对CAD,MI和SAP有独立的影响.
结论:
- 习惯性打是东亚人中CAD,MI和SAP的重要危险因素.
- 习惯性打和CAD之间的因果关系独立于BMI.
- 针对打的干预措施可能是减少亚洲人群CAD风险的可行策略.
更多相关视频
07:54Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
19.7K
03:35Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
Published on: December 1, 2023
279
相关概念视频
Sleep Apnea
131
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
131
Genome-wide Association Studies-GWAS
13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.2K
Obesity
416
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
416
Correlations
32.7K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
32.7K
