农药暴露与人类毒性之间的关联:一篇综述
S de Castro Cardoso Toniasso1, M C Borba Brum, F Lopes Dos Reis
1Postgraduate Program in Gastroenterology and Hepatology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. stoniasso@hcpa.edu.br.
European review for medical and pharmacological sciences
|February 6, 2025
概括
农药的广泛使用威胁着人类的健康. 本次审查强调,虽然没有单一的农药毒性生物标志物,但脱氧核糖核酸 (DNA) 损伤可以作为早期指标.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 人类健康风险评估
背景情况:
- 杀虫剂的使用在全球普遍,显著影响农业企业.
- 通过营养,职业和环境途径接触农药,造成健康风险.
研究的目的:
- 系统地审查和评估关于农药对人类的毒性的科学证据.
- 确定可靠的生物标志物,以评估农药暴露和不良影响.
主要方法:
- 从PubMed和Embase数据库中对人类研究 (2010-2023) 的系统审查.
- 遵守PRISMA和MOOSE指导方针,并注册PROSPERO. 这些指导方针包括:
- 搜索策略集中在人类的"杀虫剂"和"毒性",不包括动物研究.
主要成果:
- 最初的搜索产生了247篇文章;在全文审查后,包括了9篇文章.
- 没有确定农业农药暴露和毒性的最终黄金标准或单一生物标志物.
结论:
- 临床评估和可用的测试对于评估农药毒性至关重要.
- 脱氧核糖核酸 (DNA) 损伤被提议作为人类身体中农药诱导的变化的潜在早期生物标志物.
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