高纤维和低纤维饮食对抗瘤免疫力和结肠瘤进展的不同影响在小鼠模型中
Kevin E Goggin1, SeonYeong Jamie Seo1, Benjamin G Wu2,3
1Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, Kentucky.
Cancer prevention research (Philadelphia, Pa.)
|February 6, 2025
概括
低纤维饮食可以通过增强抗炎性免疫反应和细胞毒性T细胞来减少结肠癌的进展,这与高纤维饮食的预期相反. 个性化营养是预防结肠癌的关键.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 饮食纤维在结肠癌预防中的作用受到争论.
- 毒性 细菌 Fragilis 感染可以影响结肠癌的发展.
研究的目的:
- 为了研究高纤维和低纤维饮食对抗瘤免疫力和肠道微生物群的影响,APCmin/+小鼠感染了 enterotoxigenic Bacteroides fragilis.
- 了解饮食纤维对结肠癌进展的影响背后的机制.
主要方法:
- 给小鼠食高纤维,低纤维或饮食.
- 分析包括瘤负担,生存率,细胞因子概况,肠道微生物群组成和代谢物分析.
主要成果:
- 高纤维饮食与食相比,瘤负担没有显著差异.
- 低纤维饮食显著降低了瘤负担,改善了生存率.
- 高纤维增加了益炎性细胞因子和IL-17A+RORγt+调节性T细胞,而低纤维增强了抗炎性细胞因子和细胞毒性T细胞.
- 微生物群和代谢物概况在饮食组之间有显著差异.
结论:
- 食纤维对结肠癌的影响取决于微生物感染和宿主的免疫状态.
- 低纤维饮食可能在特定情况下提供保护作用,与一般假设相反.
- 个性化饮食干预对于有效的结肠癌管理至关重要.
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