在辅助生殖技术和自然受孕后,怀孕期间的睡眠质量:前性出生队列研究
Yidong Xie1,2, Ruoti Peng3, Li Xiao1,2
1Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China.
Frontiers in endocrinology
|February 6, 2025
概括
与自然受孕相比,接受体外受精/细胞内精子注射 (IVF/ICSI) 的女性在怀孕期间的睡眠质量较差,压力更高. 建议在IVF/ICSI怀孕中早期查睡眠障碍.
科学领域:
- 生殖医学 生殖医学
- 睡眠科学 睡眠科学
- 心理健康 心理健康
背景情况:
- 怀孕涉及显著的生理和心理变化.
- 怀孕期间的睡眠质量可能会受到各种因素的影响.
- 像IVF/ICSI这样的辅助生殖技术可能会影响母亲的福祉.
研究的目的:
- 调查睡眠质量与通过体外受精/细胞内精子注射 (IVF/ICSI) 与自然受精 (NC) 怀孕之间的关联.
- 评估睡眠质量与心理因素之间的关系,包括怀孕妇女的焦虑,抑郁和感知压力.
- 为了比较经过IVF/ICSI和自然受孕的女性之间的睡眠质量和心理健康.
主要方法:
- 一项前性队列研究,涉及500名接受试管婴儿/ICSI治疗的不育妇女和678名自然受孕妇女.
- 睡眠质量,焦虑,抑郁和感知压力被评估使用验证的问卷 (PSQI,SAS,CES-D,PSS) 在三个季度.
- 采用多变量后勤回归模型来分析关联,并根据潜在的混因素进行调整.
主要成果:
- 在整个怀孕期间,IVF/ICSI组的妇女报告睡眠质量明显差 (61.1%-66.5%) 与NC组相比 (43.2%-46.4%).
- 试管婴儿/ICSI组在第一和第二季度表现出更高水平的抑郁和感知压力.
- 睡眠质量差也与晚年母亲的年龄有关,但在IVF/ICSI和NC组的丈夫之间没有观察到睡眠质量的显著差异.
结论:
- 接受IVF/ICSI治疗的妇女在怀孕期间面临更高的睡眠障碍风险,与自然受孕妇女相比.
- 虽然伴侣表现出增加的焦虑,但他们的睡眠质量是可比的.
- 睡眠障碍的常规查和管理对于通过试管婴儿/ICSI改善怀孕妇女的健康状况至关重要.
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