传统和补充的替代医学疗法治疗脏贫血:文献综述
Ching-Ming Lu1,2, Yuan-Hsuan Hsu1,2, I-Hsin Lin1
1School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan.
Frontiers in endocrinology
|February 6, 2025
概括
本综述探讨了贫血的治疗方法,重点关注低氧诱导因子酸酶域 (HIF-PHD) 轴. 它强调了药物,饮食和补充疗法,包括肠道微生物组调节,以改善患者的生活质量.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 贫血是慢性病 (CKD) 患者的复杂疾病,由炎症,缺铁和减少红素蛋白 (EPO) 产生的.
- 疲劳和身体功能受损等症状显著降低了患者的生活质量.
- 缺氧诱导因子prolyl氧酶域 (HIF-PHD) 轴是治疗干预的关键目标.
研究的目的:
- 综合审查常规和补充性替代医学 (CAM) 方法来管理慢性病中的贫症.
- 讨论HIF-PHD轴理论和非体外治疗的临床应用.
- 综合目前关于药物干预,饮食策略和CAM改善脏贫血的证据.
主要方法:
- 在主要的电子数据库 (PubMed,Embase,Cochrane图书馆,CNKI,Airiti,Wanfang) 进行了系统的文献搜索.
- 该审查侧重于临床试验和试点研究,调查各种治疗方式.
- 分析包括特定药物的作用 (Roxadustat,Ferumoxytol,Epodion) 和干预措施,如肠道微生物组调节和CAM.
主要成果:
- 像Roxadustat,Ferumoxytol和Epodion这样的药物在治疗脏贫血方面表现有前途.
- 调节肠道微生物群可以减少炎症,并积极影响脏贫血.
- 通过改善铁代谢,抗炎作用以及对肝素,EPO和HIF的调节,CAM疗法显示出潜在的益处.
结论:
- 非外体治疗方法,包括药物,饮食改变和CAM,为脏贫血管理提供了可行的策略.
- 针对HIF-PHD轴和肠道微生物组为治疗开发提供了有希望的途径.
- 进一步的研究和证据综合可以为患有脏贫血的CKD患者提供有效的治疗建议.
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