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抑郁症与自然绝经年龄的关联:用NHANES数据进行横截面分析
Shuaiqi An1, Shiyan Ren1, Jiawen Ma1
1School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
International journal of women's health
|February 6, 2025
概括
抑郁症与美国女性早期更年期风险增加有关. 管理心理健康并及时寻求治疗可能会改善生殖健康结果.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 更年期是一个自然的生物过程. 影响其时间的因素,包括心理健康,具有显著的兴趣.
- 抑郁症是一种普遍存在的心理健康状况,影响着各种年龄段的女性.
研究的目的:
- 调查美国女性抑郁症和自然更年期 (ANM) 的年龄之间的联系.
- 为了确定抑郁症的严重程度是否与经历早期更年期的风险相关.
主要方法:
- 一项采用2005年至2023年国家健康和营养检查调查 (NHANES) 八个周期数据的横截面研究.
- 用患者健康问卷-9 (PHQ-9) 评估抑郁症. 自然绝经年龄 (ANM) 数据是通过生殖健康问卷收集的.
- 采用多变量逻辑回归模型来分析抑郁症和ANM之间的关联,并进行子组分析.
主要成果:
- 该研究包括4732名女性,平均ANM为47.9±6.8年. 在23.7%的参与者中观察到早期更年期.
- 在PHQ-9分数和早期更年期风险之间发现了积极的关联. PHQ-9分数每增加1个单位,就会增加7%的早期更年期风险.
- 患有严重抑郁症的女性有显著增加早期更年期的风险 (OR = 2.49).
结论:
- 美国女性抑郁症的严重程度与早期更年期风险增加有关.
- 这些发现强调了心理健康意识和管理对生殖健康的重要性.
- 早期干预和治疗抑郁症可能有助于改善生殖健康,并可能推迟更年期.
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