阿什瓦甘达在调节狗的肠道参数中的作用 - 一个随机双盲安慰剂对照试验
Kala Kumar Bharani1, Ashok Kumar Devarasetti2, Rajendar Bobbili3
1Department of Pharmacology and Toxicology, School of Veterinary and Animal Sciences, Centurion University of Technology and Management, Paralakhemundi, India.
Frontiers in veterinary science
|February 6, 2025
概括
阿什瓦甘达根提取物 (ARE) 通过增强血液标记物和调节肠道细菌,改善了老犬的肠道健康. 这表明ARE通过积极影响其微生物组,支持老年犬健康老龄化.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物组研究 微生物组研究
- 老年动物卫生老年动物卫生
背景情况:
- 肠道微生物群的健康对老龄化动物至关重要.
- 阿什瓦甘达 (Withania somnifera) 根提取物 (ARE) 具有适应性和抗炎性质.
- 研究ARE对老年犬肠道健康的影响是有必要的.
研究的目的:
- 为了评估阿什瓦甘达根提取物 (ARE) 对健康老年犬肠道微生物群参数的影响.
- 评估ARE在改善与狗健康衰老相关的重要参数方面的潜力.
- 测试ARE通过其抗炎作用促进肠道健康的假设.
主要方法:
- 进行了一项随机,双盲,安慰剂控制的试验.
- 12只健康的老年比格尔犬 (12-15岁) 接受了ARE (15 mg/kg每天2个月) 或安慰剂.
- 评估了血清血液学,生化标志物,便参数和肠道微生物群代谢物.
主要成果:
- ARE显著增加了红细胞计数和血红蛋白水平 (p < 0.01).
- ARE降低了肝脏生物标志物 (ALT,AST) 和改善了便得分 (p < 0.001).
- ARE调节L-氨酸水平,降低酸和便中的SCFA总量.
结论:
- 阿什瓦甘达根提取物 (ARE) 在老年犬中证明了肠道健康的好处.
- ARE改善了血液和生化特征,调节了L-氨酸和SCFA水平.
- 通过调节狗的肠道微生物群及其代谢物,ARE可能会减轻与年龄相关的变化.
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