低垂体雌激素受体α对于雌性鱼的性行为是必不可少的,但不保护其免受肥胖
Marissa Kraynak1,2, Molly M Willging1,2, Daniel J Uhlrich3
1Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Journal of the Endocrine Society
|February 6, 2025
概括
雌激素受体α (ERα) 在雌性海中对性行为至关重要,并影响生殖荷尔蒙和新陈代谢. 在下丘脑中击败ERα显著降低了性感受力,并改变了代谢和淋巴细胞功能.
科学领域:
- 神经内分泌学神经内分泌学
- 生殖生物学 生殖生物学
- 代谢调节 代谢调节 代谢调节
背景情况:
- 动物中的雌激素受体α (ERα) 调节性行为,生殖和新陈代谢.
- 在雌性非人类灵长类动物 (NHPs) 中,下丘脑ERα的作用仍然未被描述.
- 雌激醇 (E2) 对这些功能至关重要,但其在NHP中的特定下丘脑点是未知的.
研究的目的:
- 为了研究ERα在雌性大黄海马体下丘脑中腹中核 (VMN) 和弧形核 (ARC) 中的作用.
- 为了确定ERα淘汰是否影响性感受性,性腺功能和代谢平衡.
主要方法:
- 成年雌性海豚经历了卵巢切除和雌激素替代.
- 诱导了饮食诱导的肥胖症,随后在VMN和ARC中使用shRNA进行了选择性的ERα淘汰 (KD),并通过MRI引导的手术进行了ARC.
- 使用免疫组织化学量化ERα表达量化.
主要成果:
- ERα KD显著降低了VMN和ARC中的ERα表达.
- ERα KD导致性感受力的丧失和及时的性反应.
- ERα KD导致淋巴腺激素水平升高,高血糖症和减少卡路里消耗.
结论:
- 在女性NHP中基底下垂体中ERα激活对于性行为至关重要.
- 在雌性NHP中,ERα在调节淋巴体和代谢控制方面发挥着作用.
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