脑器官芯片上的概念验证可以在前脑器官中创建多个域
Yuan-Chen Tsai1, Hajime Ozaki1, Ango Morikawa2
1Department of Anatomy and Neurobiology, University of California Irvine CA 92697 USA momokow@uci.edu.
RSC advances
|February 6, 2025
概括
芯片上的大脑器官平台创建信号梯度以产生地形前脑器官. 这有助于推进用于神经发育和疾病研究的人类大脑建模.
科学领域:
- 神经科学是一个神经科学.
- 干细胞生物学 干细胞生物学
- 生物技术是生物技术.
背景情况:
- 大脑有机体为研究人类大脑发育和疾病提供体外模型.
- 目前的3D培养方法很难复制体内发现的生理信号梯度.
- 复制体内条件对于准确的疾病建模和药物发现至关重要.
研究的目的:
- 开发一种新的脑器官在芯片上的平台,能够产生信号梯度.
- 诱导具有连续频谱的大脑区域的拓前脑器官.
- 提高人类大脑模型研究神经发育和疾病的可靠性.
主要方法:
- 利用多能干细胞产生大脑器官.
- 工程脑器官在芯片上的系统,以建立受控的信号梯度.
- 在芯片平台内诱导拓前脑有机体.
主要成果:
- 在芯片上的有机体系统中成功生成稳定的信号梯度.
- 实现了对地图前脑器官的诱导,模仿了一系列大脑区域的频谱.
- 展示了一个更全面的人类大脑体外模型.
结论:
- 大脑的器官在芯片上的平台有效地重建生理信号梯度.
- 这项技术可以生成更准确,更详细的人类大脑发育和疾病模型.
- 为神经发育研究和疾病评估提供了前所未有的潜力.
相关概念视频
Anatomy of the Brain: Major Regions
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
Association Areas of the Cortex
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Cerebellum: Anatomical Regions
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
Cerebrospinal Fluid
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
Organization of the Brain
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Brain Imaging
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).


