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氧化平衡得分与胆结石疾病之间的关联:来自NHANESES的一项基于人口的研究

Mengmeng Zhang¹, Aiming Yang¹

¹Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Frontiers in nutrition

|February 6, 2025

概括

较高的氧化平衡评分 (OBS),反映出均衡的饮食和生活方式,与胆结石风险降低有关. 这表明富含抗氧化剂的饮食和健康的习惯可以防止胆结石的形成.

科学领域:

营养科学营养科学
代谢健康代谢健康
流行病学流行病学

背景情况:

氧化应激与胆结石的发病有关.
氧化平衡评分 (OBS) 将饮食和生活方式的亲氧化剂/抗氧化剂暴露与代谢障碍联系起来.
OBS和胆结石之间的关系尚未得到充分理解.

研究的目的:

调查氧化平衡得分 (OBS) 与胆结石风险之间的关联.
探索饮食和生活方式因素在胆结石发育中的作用.
为了确定OBS-Gallstone关系中的潜在调解者.

主要方法:

对NHANES 2017-2020年数据 (n=7,618) 的横截面分析.
从24小时的饮食回忆/问卷计算的OBS.
采用加权后勤回归,受限立方线 (RCS),加权量子素和 (WQS) 和贝叶斯内核机器回归 (BKMR) 模型.
进行了子组,敏感性和调解分析.

主要成果:

总的OBS与胆结石风险相反相关 (OR=0.98,p=0.03).
饮食和生活方式 OBS 独立保护胆结石.
在OBS和胆结石之间观察到非线性关系 (p=0.03).
影响OBS和胆结石风险的关键成分包括BMI,维生素E,维生素B6,和胡卜素.
血清甘油三和HDL调解了这种关联.

结论:

氧化平衡增加与胆结石风险降低有关.
这些发现支持促进富含抗氧化剂的饮食和健康生活方式的干预措施,以预防胆结石.
OBS可以作为胆结石疾病监测的有价值指标.

关键词:

尼汉斯 (NHANES) 是一个名人.饮食饮食饮食饮食胆结石胆结石胆结石生活方式生活方式氧化平衡得分氧化平衡得分

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