氧化平衡得分及其与慢性炎症性呼吸道疾病和死亡率的关联:基于人口的研究
Zhuanbo Luo1, Shiyu Chen1, Peixu Chen1
1Department of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Ningbo, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Frontiers in nutrition
|February 6, 2025
概括
较高的氧化平衡评分 (OBS) 与较低的慢性炎症性呼吸道疾病 (CIAD) 发生率有关,包括喘和COPD. 改善的OBS还可以降低CIAD患者的死亡风险,强调饮食和生活方式.
科学领域:
- 营养流行病学 营养流行病学
- 呼吸系统医学 呼吸系统医学
- 公共卫生 公共卫生
背景情况:
- 氧化压力在慢性炎症性呼吸道疾病 (CIAD) 中发挥着作用.
- 氧化平衡评分 (OBS) 量化了影响氧化平衡的饮食和生活方式因素.
- 了解OBS和CIAD患病率/死亡率之间的联系对于公共卫生至关重要.
研究的目的:
- 调查联合氧化平衡得分 (OBS) 与CIAD的患病率之间的关联.
- 检查OBS与被诊断患有CIAD的个体的死亡率之间的关系.
- 探索饮食和生活方式因素对呼吸系统健康结果的影响.
主要方法:
- 利用了2013-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 根据16种营养素和4种生活方式因素计算的OBS,分为四分之一.
- 采用后勤和COX回归模型来分析OBS,CIAD流行率和死亡率之间的关联.
主要成果:
- 较高的OBS四分位数与较低的总CIAD,喘,慢性支气管炎和COPD的患病率显著相关.
- 在OBS和呼吸系统疾病发病率之间观察到线性,反向的关系.
- 在OBS四分位数最高的人群中,所有原因和呼吸道疾病的死亡风险显著降低.
结论:
- 升高的OBS是防止CIAD流行的一个重要保护因素.
- 较高的OBS水平与慢性炎症呼吸道疾病患者的死亡率降低有关.
- 正如OBS所反映的饮食和生活方式的修改,可能在CIAD预防和管理中发挥关键作用.
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