胃癌手术后肠道微生物群的变化:一项前性的纵向研究
Yuhua He1, Shilin Gao1, Lili Jiang1
1Colorectal Cancer Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China.
Frontiers in oncology
|February 6, 2025
概括
胃癌手术并没有改变肠道微生物群的多样性,但显著改变了其组成. 关键的细菌类和属在胃切除术后发生了转移,这表明肠道微生物群的结构性改变.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 胃癌是全球重要的健康问题.
- 胃切除术是一种用于胃癌的手术,可能会影响肠道微生物群.
- 了解这些变化对于患者的康复和管理至关重要.
研究的目的:
- 在胃癌患者的肠道微生物群变化的特征.
- 为了比较胃切除术前后的肠道微生物多样性和结构.
- 为了确定受手术影响的特定细菌种群.
主要方法:
- 使用了16S核糖体RNA (rRNA) 基因测序.
- 分析了60名胃癌患者 (共120人) 的便样本.
- 评估了微生物群多样性 (α和β) 和结构组成.
主要成果:
- 胃切除术后没有观察到肠道微生物群多样性的显著变化 (Chao1,Shannon,Simpson指数).
- 在族群和属层面检测到微生物结构的显著变化.
- 减少了Bacteroidota,Synergistota,Verrucomicrobiota,Bacteroides,Faecalibacterium,Blautia和Lachnospiraceae nk4a136组的丰富性. 这是一个很大的问题.
- 增加了Campylobacter,Actinobacteria,Bacillota,Porphyromona,Finegordia,Dialist,Anaerococcus和Corynebacterium的丰富性. 这种细菌的数量可能会增加.
结论:
- 胃切除术不会显著改变胃癌患者的肠道微生物群多样性.
- 在胃切除术后,肠道微生物社区结构发生显著变化.
- 这些结构变化需要进一步研究其临床影响.
相关概念视频
What is Monogastric Digestion?
70.5K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.5K
Anatomy of the Intestines
71.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.3K
Peptic Ulcer Disease V: Surgical Management and Nursing Care
200
Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
Surgical Interventions for Peptic Ulcer Disease
200
Inflammatory Bowel Disease V: Surgical Management
103
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
103
Bacterial Flora of the Large Intestine
375
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
375
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
39
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
39


