高密度脂蛋白胆固醇对血液恶性瘤风险的不一致影响:全国性队列研究
Su Youn Nam1, Junwoo Jo2, Won Kee Lee3
1Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Journal of lipid and atherosclerosis
|February 6, 2025
概括
低高密度脂蛋白胆固醇 (HDL-C) 水平增加白血病和淋巴瘤的风险. 吸烟和更年期状态影响这些关联,特别是目前吸烟者和更年期后妇女的白血病.
科学领域:
- 流行病学 流行病学
- 心血管健康 心血管健康
- 在瘤学瘤学.
背景情况:
- 众所周知,高密度脂蛋白胆固醇 (HDL-C) 与血液恶性瘤有相反的关系.
- 吸烟对这种关联的影响以前没有报告过.
研究的目的:
- 研究吸烟和更年期状态如何改变HDL-C水平和血液恶性瘤之间的关联.
- 为了检查患有淋巴瘤和白血病的风险,与不同的HDL-C水平相关.
主要方法:
- 一项以人口为基础的队列研究包括2010年选的超过450万名无癌症个体,随访期至2017年.
- 参与者的HDL-C水平被分为八个10 mg/dL间隔.
- 调整后的危险比率 (aHR) 被计算出来,以评估HDL-C水平的恶性瘤风险,考虑到吸烟和更年期状态.
主要成果:
- 与70-79 mg/dL范围相比,较低的HDL-C水平与淋巴瘤 (aHR,1.83),白血病 (aHR,3.14) 和未指定的血液恶性瘤 (aHR,2.34) 的风险增加显著相关.
- 低HDL-C和白血病风险之间的关联在吸烟状态之间是一致的.
- 极高的HDL-C水平与目前吸烟者的白血病风险更高有关 (aHR, 2.32),而低的HDL-C仅在从未吸烟的人中构成淋巴瘤风险 (aHR, 2.01).
- 低HDL-C对白血病的危险影响在绝经后妇女中特别观察到 (aHR,2.94).
结论:
- 较低的HDL-C水平是患白血病和淋巴瘤的危险因素.
- 高血脂-C和血液恶性瘤之间的关系是由吸烟状态和更年期状态调节的,这表明不同亚组的风险概况不同.
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