与代谢功能障碍相关的脂肪性肝病患者治疗失脂症的实用方法
Fernando Bril1, Gabriela Berg2,3, Magali Barchuk2,3
1Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, AL, USA.
Journal of lipid and atherosclerosis
|February 6, 2025
概括
管理失脂症和与代谢功能障碍相关的脂肪性肝病 (MASLD) 一起是具有挑战性的. 本综述涵盖了针对这两种疾病的当前和新兴治疗方法,强调了整体方法.
科学领域:
- 肝病学和内分泌学.
- 心血管医学 心血管医学
背景情况:
- 失脂症是显著的心血管疾病风险因素,通常由代谢功能障碍相关的脂肪性肝病 (MASLD) 恶化.
- 胰岛素抵抗与MASLD和脂质失调有关,需要综合管理策略.
- 共同管理这些疾病带来了重大的临床挑战.
研究的目的:
- 阐明MASLD和脂质障碍症之间的病理生理联系.
- 对MASLD和脂质失调症患者的降脂剂和降糖剂的当前治疗指南进行审查.
- 探索针对MASLD/代谢功能障碍相关的脂肪肝炎 (MASH) 和脂质失调症的新疗法.
主要方法:
- 关于MASLD和脂质失调的现有研究的综合文献综述.
- 对药物治疗当前临床实践指南的分析.
- 检查新兴药物类别及其潜在应用.
主要成果:
- 确立了MASLD和脂质不良症之间的病理生理联系.
- 已批准和正在研究的药物的概述,用于管理同时存在的MASLD/MASH和脂质失调症.
- 识别治疗缺口和未来研究方向.
结论:
- 整体方法对于管理患有MASLD和失脂症的患者至关重要.
- 目前的治疗方法提供了选择,但新兴的疗法有望实现双重作用.
- 进一步了解潜在机制将有助于改善临床管理.
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