使用β-乳糖球蛋白的先进药物输送系统:一种高效的基于蛋白质的药物载体
Charan M Gowda1, Sanjay Sharma1, Sarika Wairkar1
1Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, Mumbai, India.
Biopolymers
|February 6, 2025
概括
乳清蛋白质是一种乳清蛋白质.
科学领域:
- 生物材料科学 生物材料科学
- 制药科学 制药科学
- 蛋白质化学 蛋白质化学
背景情况:
- 由于特定的药物结合能力,蛋白质,特别是乳清蛋白 (WP) 被探索为药物递送系统 (DDS).
- 作为乳清蛋白的主要成分的β-乳糖球蛋白 (BLG) 具有有利的特性,如热稳定性和药物输送应用的有利电荷.
- 包括纳米颗粒和水凝在内的各种基于BLG的DDS已经开发出来,以提高药物的溶解性,生物可用性和向性输送.
研究的目的:
- 审查β-乳糖球蛋白 (BLG) 作为药物输送系统 (DDS) 中多功能载体的作用和应用.
- 要突出基于BLG的DDS如何改善药物特性和治疗结果.
- 讨论未来的方向和挑战,以BLG为基础的药物交付.
主要方法:
- 在各种药物输送系统 (DDS) 中使用β-乳糖球蛋白 (BLG) 的研究文献综述.
- 对BLG在药物封装和释放方面相关的功能性质的分析.
- 检查基于BLG的DDS的各种应用和未来潜力.
主要成果:
- 在众多DDS (纳米粒子,水凝等) 中,BLG充当了多功能载体. ),提高药物的溶解性,生物可用性和稳定性.
- 基于BLG的DDS在各种应用中表现出有效性,包括癌症治疗和口服药物输送.
- BLG提供可控药物释放和降低毒性,彻底改变了制药应用.
结论:
- β-乳糖球蛋白 (BLG) 是先进药物递送系统 (DDS) 的一个非常有前途的载体.
- 基于BLG的DDS在药物疗效和患者治疗方面提供了显著的改善.
- 未来的研究应该专注于优化BLG载体降解,生物相容性和免疫反应.
相关概念视频
Drug Distribution: Plasma Protein Binding
4.8K
Drugs predominantly attach to plasma proteins, with only a small percentage remaining unbound. The unbound portion can be calculated as one minus the bound fraction. Acidic drugs form large, inactive complexes by reversibly binding to plasma albumin, which prevents them from diffusing across biological barriers. These drug-protein complexes act as reservoirs for the drugs. As the concentration of unbound drugs decreases, these complexes quickly dissociate to release the free drug, maintaining...
4.8K
Factors Affecting Protein-Drug Binding: Drug-Related Factors
73
Drug binding to proteins is a complex phenomenon influenced by various drug-related factors, each playing a significant role in the interaction between drugs and proteins within the body.
One crucial factor in drug-protein binding is the drug's lipophilicity or its affinity for fat. More lipophilic drugs tend to have higher binding extents. For example, highly lipophilic drugs like cloxacillin exhibit substantial protein binding, with as much as 95% of the drug binding to proteins. In...
One crucial factor in drug-protein binding is the drug's lipophilicity or its affinity for fat. More lipophilic drugs tend to have higher binding extents. For example, highly lipophilic drugs like cloxacillin exhibit substantial protein binding, with as much as 95% of the drug binding to proteins. In...
73
Carrier-Mediated Transport
239
Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
239
Drug Delivery: Overview
274
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
274
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport
3.5K
Certain large, lipid-insoluble drug molecules that resemble amino acids, peptides, or glucose, require specialized carrier proteins to facilitate their diffusion across cell membranes. This transport can occur through either facilitated diffusion, which does not require energy input, or active transport, which does require energy input.
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
3.5K


