骨质疏松症和阻塞性睡眠呼吸暂停:手术结果和与一般人群的比较
Claudio Gomez Ascencio1, Anna Wani1, Ron B Mitchell1
1University of Texas Southwestern Medical Center, Dallas, Texas.
概括
患有骨质疏松症和阻塞性睡眠呼吸暂停 (OSA) 的儿童更早出现,并且在中度至重度的OSA中受益于腺切除术. 像宫骨髓解压这样的手术干预也改善了呼吸暂停-呼吸暂停指数.
科学领域:
- 儿科睡眠医学 儿科睡眠医学
- 遗传学和罕见疾病
- 外科手术的结果
背景情况:
- 无粒细胞形成症是一种遗传性疾病,其特征是不成比例的矮体.
- 阻塞性睡眠呼吸暂停 (OSA) 是患有无形质细胞增生症的儿童常见的并发症.
- 了解这一群体的人口结构和治疗疗效至关重要.
研究的目的:
- 为了将患有骨质疏松症和OSA的儿童的人口统计数据与一般儿科OSA人口进行比较.
- 为了评估儿童的手术治疗结果,阿德罗普拉西亚和OSA.
- 为了确定发病年龄和治疗反应的差异.
主要方法:
- 对22名患有骨质疏松症和OSA的儿童和141名患有OSA的对照儿童的回顾性图表审查.
- 在外科手术之前和之后对多睡眠学参数的分析.
- 基线特征的比较,在阿德罗普拉西亚和对照组之间.
主要成果:
- 与对照组 (6.8岁) 相比,患有无形质症和OSA的儿童在显著较年轻的年龄 (3.1岁) 进行腺切除术.
- 在中度至重度OSA患者的腺切除术导致阻塞性呼吸暂停-呼吸暂停指数和氧和度的改善.
- 单独的腺膜切除术并没有显著改变OSA,而宫髓压缩减压则改善了阻塞性呼吸暂停-呼吸暂停指数.
结论:
- 患有无粒细胞形成症和OSA的患者与非无粒细胞形成症的同行相比,表现出较早的发病年龄.
- 腺切除术是一种有效的治疗中度至重度的OSA在儿童患有骨质疏松症.
- 宫髓压缩减压在这个人群中为改善OSA提供了潜在的好处.
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