临床实践中的短链脂肪酸:我们在哪里?
Robert G Martindale1, Manpreet S Mundi2, Ryan T Hurt2
1Department of Surgery, Oregon Health Sciences University, Portland, Oregon.
短链脂肪酸 (SCFA),曾经认为只影响肠道,具有广泛的抗炎和免疫作用. 使用SCFA的饮食策略显示出治疗代谢,免疫和神经退行性疾病的前景.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 代谢科学 代谢科学
背景情况:
- 传统上,人们认为短链脂肪酸 (SCFA) 对肠道粘膜有局部影响.
- 新出现的证据凸显了它们显著的系统性影响,包括抗炎和免疫调节性质.
研究的目的:
- 审查最近关于SCFA系统性影响的科学证据.
- 探索SCFA作为食基质的扩大临床应用.
主要方法:
- 对目前关于SCFA机制和影响的研究进行系统审查.
- 对SCFA在各种疾病条件中的作用的证据分析.
主要成果:
- 通过G蛋白合受体 (GPRs) 和基因素脱乙酶 (HDAC) 抑制,SCFA具有系统性作用.
- 观察到的好处包括抑制食欲,减少炎症,提高胰岛素敏感性,增加能量消耗,改善线粒体功能,增加腹感,降低血压和改善认知功能.
结论:
- 饮食干预措施应纳入SCFA,以应对广泛的疾病.
- 益生菌纤维和SCFA产生的补充剂是代谢,免疫和神经退行性疾病的潜在治疗点.
更多相关视频
06:45Author Spotlight: Optimizing Hollow-Fiber Membranes for Continuous Liquid-Liquid Extraction of Medium-Chain Fatty Acids
Published on: August 9, 2024
07:15An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Products of the Citric Acid Cycle
Chronic Pancreatitis II: Collaborative Care
Assessment:
Lipid Digestion
Bacterial Flora of the Large Intestine
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
Acute Pancreatitis II: Clinical Manifestations and Management
