发酵豆蛋白水解剂的睡眠增强活性,具有增强的GABA含量,由Lactobacillus brevis SYLB 0016发酵发酵
Hyeon Deok Kim, Hyung Joo Suh1, Seok Hyun Chung1,2
1Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea.
Journal of the science of food and agriculture
|February 6, 2025
概括
发酵豆蛋白水解剂 (PPF) 与增强的胺黄油酸 (GABA) 显著增加了小鼠的睡眠时间和非快速眼动 (NREM) 睡眠. 这种低过敏性化合物有望改善睡眠质量和解决睡眠障碍.
科学领域:
- 营养科学 营养科学
- 神经科学是一个神经科学.
- 生物化学 生化学
背景情况:
- 睡眠对于健康和福祉至关重要.
- 发酵豆蛋白水解剂 (PPF) 与增强的胺黄油酸 (GABA) 被研究了促进睡眠的影响.
- 乳酸菌 SYLB 0016 用于发酵以增加GABA含量.
研究的目的:
- 为了研究发酵豆蛋白水解盐 (PPF) 具有增强GABA含量的促进睡眠效果.
- 在动物模型中评估PPF对睡眠时间和结构的影响.
- 探索涉及GABA受体的潜在机制.
主要方法:
- 豆蛋白的水解和发酵由乳杆菌SYLB 0016来增加GABA含量.
- 在ICR小鼠和SD大鼠使用电脑电图 (EEG) 诱导的睡眠模型中评估PPF对睡眠的影响.
- 对GABA受体表达 (GABAA和GABAB) 的分析以及GABAA受体二甲胺部位的作用.
主要成果:
- 发酵显著增加了PPF中的GABA含量.
- 服用PPF显著增加了总睡眠时间和非快速眼动 (NREM) 睡眠时间,增加了δ波活动.
- PPF提高了GABAA和GABAB受体表达,同时服用弗卢马塞尼尔减少了PPF诱导的睡眠,证实了GABAA受体的参与.
结论:
- 有增强GABA含量的发酵豆蛋白水解剂 (PPF) 通过增加δ波活动来改善NREM睡眠.
- PPF显示出作为减轻睡眠障碍的低过敏补充剂的潜力.
- 这些发现突出了GABAA受体二zepine位点在PPF增强睡眠效果中的作用.
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