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对SARS-CoV-2抗原的抗体减少并不反映中和率的减少:在怀孕期间接种疫苗后评估动态和动态幽默免疫反应的前性研究
Gabriela Mattoso Coelho1, Hellen Geremias Dos Santos2, Allan Henrique Depieri Cataneo1
1Laboratory of Molecular Virology, Carlos Chagas Institute/Fiocruz, Curitiba, Paraná, Brazil.
孕妇对COVID-19疫苗表现出强烈的免疫反应,疫苗接种后中和IgG抗体显著增加. 这表明这种高风险群体对SARS-CoV-2的强大保护.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 孕产妇健康 孕产妇健康
背景情况:
- 孕妇面临严重COVID-19的更高风险.
- 最初的COVID-19疫苗试验排除了孕妇,限制了安全性和有效性数据.
- 了解怀孕期间的疫苗诱导免疫力对于公众健康至关重要.
研究的目的:
- 为了比较孕妇对BNT162b2 (Pfizer-BioNTech) 和CoronaVac (Sinovac Biotech) 疫苗的免疫反应.
- 分析中和和IgG抗体对抗SARS-CoV-2疫苗接种后的动力学和标位.
- 评估疫苗在怀孕期间的有效性和保护.
主要方法:
- 一组怀孕妇女接受了BNT162b2或CoronaVac.
- 测量了针对SARS-CoV-2抗原的IgG抗体,使用多重珠子测定.
- 使用活病毒光减少中和试验 (FRNA) 量化中和抗体.
- 在接种疫苗之前和每剂接种疫苗后30天收集样本.
主要成果:
- 疫苗接种在孕妇中诱导了强大的幽默性免疫反应.
- 在第一剂疫苗接种后,观察到IgG和中和抗体的显著增加.
- 在接种疫苗后,观察到持续的中和抗体反应.
- 抗尖峰IgG水平在第二剂后略有下降,而中和保持稳定.
结论:
- 孕妇接种COVID-19疫苗会引起中和抗体的大量增加.
- 这些发现支持SARS-CoV-2疫苗在怀孕期间的安全性和免疫性.
- 进一步的研究可能会探索抗体的长期持久性和保护.
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