在丹佛动物园的狮子,老虎和子中爆发了SARS-CoV-2疫情
Emily N Gallichotte1, Laura Bashor1, Katelyn Erbeck2
1Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
mSphere
|February 6, 2025
概括
丹佛动物园的SARS-CoV-2感染了狮子,老虎和,狮子表现出长时间的病毒RNA分泌和复发. 所有动物都产生了中和抗体,这表明一种罕见变异的单一人与动物传播事件发生了.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 传染性疾病 传染性疾病
- 动物医学是动物医学.
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 已经感染了许多动物物种,包括动物园中的动物.
- 了解动物园动物中SARS-CoV-2感染动态对于公共卫生和动物福利至关重要.
- 有限的纵向数据存在于动物园的食肉动物病毒动力学和清除.
研究的目的:
- 从现有文献中审查和比较老虎和狮子的SARS-CoV-2感染情况.
- 在丹佛动物园 (Denver Zoo) 在四个月的时间内调查SARS-CoV-2在狮子,老虎和身上爆发的情况.
- 分析病毒RNA分泌,传染性病毒存在以及受影响动物园动物的抗体反应.
主要方法:
- 在老虎和狮子中对SARS-CoV-2的文献综述,比较感染参数.
- 长度采样 (4个月) 狮子,老虎和的病毒RNA (vRNA).
- 检测传染性SARS-CoV-2并测量中和抗体标位.
主要成果:
- 与老虎和相比,狮子的vRNA水平显著更高,病毒复发的频率更高.
- 传染性病毒检测与高vRNA水平相关,并且在感染早期更为常见.
- 所有动物在感染后4个月内都产生了强大的中和抗体标位.
- 爆发菌株是一种罕见的三角洲系AY.20变种,表明单一的人类溢出事件.
结论:
- 狮子可能会经历长时间的SARS-CoV-2脱落和病毒复发.
- 从受感染的人体中单次引入SARS-CoV-2可能导致动物园内的物种间传播.
- 持续的监测和研究对于管理动物群体中的SARS-CoV-2和防止进一步传播至关重要.
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