在津巴布韦艾滋病毒感染的近青春期男孩中减少骨密度积累
Lisha Jeena1, Rashida A Ferrand2,3, Victoria Simms3,4
1Oxford Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, Oxford.
AIDS (London, England)
|February 6, 2025
概括
与没有艾滋病毒 (CWOH) 的儿童相比,艾滋病毒感染儿童 (CWH) 的骨密度积累减少,特别是男孩. 然而,在CWH中,骨密度在晚年青春期增加,这表明恢复的可能性.
科学领域:
- 儿童骨健康问题
- 传染病 传染病 传染病
- 撒哈拉以南非洲地区的公共卫生
背景情况:
- 在近青春期,骨密度积累对于终身骨健康至关重要.
- 患有艾滋病毒 (CWH) 的儿童可能会因为感染及其治疗而面临骨发育的独特挑战.
- 了解CWH的骨密度变化对于优化其长期健康结果至关重要.
研究的目的:
- 为了比较患有艾滋病毒的近青春期儿童 (CWH) 与没有艾滋病毒的儿童 (CWOH) 一年内积累的骨密度.
- 为了确定与骨密度积累相关的风险因素,在CWH.
主要方法:
- 在津巴布韦城市进行了一项前性队列研究.
- 参与者包括接受抗逆转录病毒治疗的CWH和年龄匹配的CWOH,年龄为8-16岁.
- 双X射线吸收计 (DXA) 测量了骨矿物质表面密度 (BMAD) 和骨矿物质含量 (BMC) 的瘦体质 (LBM),使用线性回归分析积累差异和风险因素.
主要成果:
- 与没有艾滋病毒的男孩相比,艾滋病毒感染的男孩的骨密度积累明显较低.
- 在艾滋病毒感染和没有感染的女孩之间,没有观察到骨密度积累的显著差异.
- 在艾滋病毒感染的男孩中,较高的病毒载荷和使用特诺福维尔二氧化 fumarate 与较少的骨密度增加有关,而较晚的青春期阶段 (IV-V) 与更大的收益有关.
结论:
- 患有艾滋病毒的近青春期男孩表现出骨积累受损,受到病毒载荷和特定抗逆转录病毒治疗的影响.
- 在CWH中,骨密度缺陷可能会在晚期青春期发育过程中显示出纠正的潜力.
- 需要进一步的研究和监测,以支持CWH的最佳骨健康.
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