在癌症患者中的状硬化
Amaris N Geisler1, Shivani Jain2, Kara Long Roche3
1Department of Dermatology, Emory University School of Medicine, Atlanta, GA.
Journal of lower genital tract disease
|February 6, 2025
概括
癌症疗法,特别是激素疗法,与女性患者的状硬化 (LS) 的发展有关. 在癌症治疗期间管理LS往往需要升级治疗由于独特的挑战.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
背景情况:
- 状硬化 (LS) 是一种慢性炎症性皮肤疾病.
- 癌症治疗与LS发展之间的关联尚未得到充分证实.
研究的目的:
- 描述癌症疗法与状样硬化 (LS) 的发展之间的关联.
- 分析癌症治疗期间发生LS的患者的临床和治疗特征.
主要方法:
- 在纪念斯隆凯特林癌症中心 (2003-2019) 癌症治疗期间诊断出LS的患者的回顾性图表审查.
- 在癌症治疗之前被诊断患有LS的患者的排除.
- 对临床和治疗特征的分析.
主要成果:
- 29名女性患者在全身癌症治疗期间发展了LS.
- 到LS发病的中位时间为420天.
- 乳腺癌 (34.5%) 是最常见的原发性瘤;荷尔蒙疗法 (34.5%) 是最常见的治疗方案.
- 大多数患者 (69.6%) 需要在初始超强的局部类固醇之外进行升级的LS治疗.
结论:
- 激素治疗是一种常见的癌症治疗,与LS发展有关.
- 在癌症患者中管理LS存在挑战,原因是重叠的病理生理学和治疗机制.
- 仅有有限的数据可指导该群体的LS治疗,因此需要对这两种情况进行密切跟踪.
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