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Updated: Jun 13, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

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评估治疗性寡核酸的杂交依赖的目标外风险:更新的行业建议.

Patrik Andersson1, Sebastien A Burel2, Heather Estrella3

  • 1AstraZeneca R&D, Gothenburg, Sweden.

Nucleic acid therapeutics
|February 6, 2025
PubMed
概括

更新的指导方针解决了寡核酸治疗药物 (ONT) 的安全性,详细说明了五步框架,以识别,评估和管理依赖于杂交的非目标效应,这对于临床试验的进展至关重要.

关键词:
在ASO的基础上,ASO是ASO.这是一个依赖于杂交的杂交.在Silico预测预测中远离目标 - 远离目标生产的采用生产的采用.风险评估 风险评估 风险评估siRNA 是一个RNA.治疗性寡核酸治疗性寡核酸

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