在分布式研究网络中的眼科和瘤学中,贝瓦齐祖马布的患者特征和使用情况
Jenice S Ko1, Aaron B Mendelsohn1, Kimberly Daniels2
1Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA.
Journal of managed care & specialty pharmacy
|February 6, 2025
概括
贝瓦西祖马布及其生物仿制药在眼科和瘤学中越来越多地使用,近年来生物仿制药的采用量显著增加. 美国生物仿制药使用的真实数据仍然有限,需要进一步监测.
科学领域:
- 药物经济学和健康研究成果研究成果
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
背景情况:
- 有限的现实世界数据存在于bevacizumab及其生物类似物在美国,特别是眼科条件.
- 贝瓦西祖马布广泛用于瘤和眼科的适应症.
- 了解原始药与生物类似药贝瓦齐祖马布的使用模式至关重要.
研究的目的:
- 评估和比较原始者贝瓦西祖马布与其生物类似药的使用模式和患者特征.
- 分析bevacizumab在标记和非标记瘤和眼科条件中的使用.
- 在瘤学适应症中描述与贝瓦齐祖马布相关的不良事件.
主要方法:
- 使用生物药物和生物类似药物集体情报联盟数据库进行的回顾性队列研究.
- 包括在2010年1月1日至2021年6月30日期间接受贝瓦齐祖马布的21岁以上患者.
- 对瘤学 (结肠癌,肺癌,妇科癌) 和眼科 (AMD,RVO,CNV,PDR) 指示的人口统计和临床特征的分析.
主要成果:
- 在大多数适应症中,贝瓦西祖马布产品的使用量增加,眼科用途 (RVO,CNV,PDR) 在2015年后增加.
- 瘤生物类似药的使用在2019-2020年间大幅增加 (例如,结肠癌从6.2%增加到49.4%).
- 眼科 (主要是男性,较低的并发症) 和瘤 (主要是女性,较高的并发症) 指示之间,患者人口结构有所不同.
结论:
- 在研究期间,bevacizumab产品的使用范围扩大到各种指示.
- 在研究的后期几年,生物类似贝瓦西祖马布的采用量增长,市场上市后的可用性.
- 需要进一步的研究来监测美国贝瓦西祖马布生物仿制剂的现实世界使用和不良事件.
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