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牛皮关节炎临床试验中的成像:一个范围审查

Andrew Xiao¹, Ainge Roy², Liz Dennett³

¹Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.

Skeletal radiology

|February 6, 2025

概括

本综述强调了成像如何在牛皮关节炎 (PsA) 临床试验中使用. 放射学和MRI的标准化评分系统正在推进PsA评估,但超声波需要更多的标准化.

科学领域:

类风湿病学类风湿病学
医疗成像医学成像
临床试验临床试验

背景情况:

牛皮关节炎 (PsA) 是一种慢性炎症性疾病,影响皮肤和关节,影响生活质量.
精确的诊断,进展监测和PsA治疗评估在很大程度上依赖于医学成像.
图像在牛皮关节炎的临床试验中发挥着关键作用.

研究的目的:

在牛皮关节炎临床试验文献中审查和描述各种成像模式和技术的利用.
为了确定PsA研究成像的趋势和进步.

主要方法:

使用Arksey和O'Malley框架进行了全面的范围审查.
从2000年1月1日到2024年6月27日,文学数据库进行了搜索,产生了1961篇文章.
在经过严格的分复制和选过程后,包括了53项研究.

主要成果:

射线图是最常见的方法 (60%),通常使用PsA修改的夏普/范德海德得分来确定进展.
核磁共振 (30%) 评估了外周和轴心疾病,越来越多地使用了PsAMRIS和SPARCC得分.
超声波 (21%) 评估了软组织炎症;像GLOESS这样的标准化评分系统未得到充分利用.

结论:

放射和MRI的PsA特定评分系统在临床试验中显著改善了成像评估.
需要更广泛地采用这些标准化评分系统,特别是超声波,这需要进一步标准化.
未来的PsA试验应纳入先进的成像技术和多模式方法,以加强疾病监测.

关键词:

临床试验中的临床试验.图像成像是一种成像.牛皮关节炎牛皮关节炎放射学放射学是一门学科.范围审查范围审查

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