通过静脉BCG介导的抗结核保护需要CD4+ T细胞和CD8α+淋巴细胞
Andrew W Simonson1,2, Joseph J Zeppa1,2, Allison N Bucsan3
1Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
静脉BCG接种疫苗可以预防的结核病. CD4 T 细胞对于这种保护至关重要,而非传统的 CD8α 淋巴细胞也在预防 Mycobacterium 结核病感染方面发挥着重要作用.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 微生物学 微生物学
背景情况:
- 结核病 (结核病) 仍然是一个全球卫生挑战,尽管广泛的Bacillus Calmette-Guérin (BCG) 疫苗接种.
- 之前的研究表明静脉注射 (IV) 接种BCG疫苗可以预防非人类灵长类动物感染Mycobacterium tuberculosis (Mtb) 感染.
研究的目的:
- 阐明免疫机制的基础保护赋予了IV. 对结核病的BCG疫苗接种.
- 为了确定特定的淋巴细胞子集,对静脉注射至关重要. 通过BCG介导的保护.
主要方法:
- 接种了静脉注射疫苗的. 在MTB挑战之前和期间,BCG受到了淋巴细胞子集枯竭.
- 在耗尽和挑战之后,评估了Mtb负担和传播.
主要成果:
- 适应性CD4T细胞的耗尽取消了保护,导致Mtb负担和传播增加.
- 适应性CD8αβT细胞对于静脉注射并非必不可少. 通过BCG介导的保护.
- 非传统的CD8α表达性淋巴细胞 (NK细胞,天生的T细胞,CD4+CD8α+T细胞) 的耗尽也影响了保护.
结论:
- CD4 T 细胞对于静脉注射的保护效果至关重要. 对结核病的BCG疫苗接种.
- 非传统的CD8α表达性淋巴细胞也可能导致静脉注射. 由BCG引起的保护,需要进一步调查.
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