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化疗后患有淋巴瘤的儿科患者的身体组成变化:一项回顾性研究
Nathalia Farache Tostes1, Beatriz Pereira de Carvalho2, Isabella Caroline Santana Aleixo3
1Post-Graduated Program in Nutrition, Food and Health, Nutrition Institute, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.
European journal of pediatrics
|February 6, 2025
概括
化疗改变了儿科淋巴瘤患者的身体组成,增加了脂肪组织和肌肉质量,但减少了肌肉密度. 特定的协议,如EURONET和诊断,如霍奇金淋巴瘤显示显著的脂肪组织收益.
科学领域:
- 儿科瘤学 儿科瘤学
- 身体组成分析分析.
- 癌症治疗效果 癌症治疗效果
背景情况:
- 化疗对成人癌症患者的身体组成产生负面影响,减少肌肉质量.
- 计算机断层扫描 (CT) 评估成人的身体组成,包括肌肉和脂肪组织.
- 接受化疗的儿童癌症患者经历了根据方案而异的身体组成变化.
研究的目的:
- 为了研究小儿淋巴瘤患者的化疗诱导的身体组成变化.
- 分析不同化疗方案和诊断对身体组成的影响.
- 评估化疗后骨肌肉和脂肪组织参数的变化.
主要方法:
- 在2017-2021年期间接受治疗的49名淋巴瘤患者 (6-18岁) 的回顾性观察研究.
- 使用CT分析L3区域的身体组成,测量骨肌面积 (SMA),密度 (SMD),psoas肌面积 (PMA),皮下脂肪组织 (SAT),内脏脂肪组织 (VAT) 和肌内脂肪组织 (IMAT).
- 配对的t测试和克鲁斯卡尔-瓦利斯测试比较了治疗前和后的参数,并按协议/诊断分层变化.
主要成果:
- 在化疗后,观察到SAT,VAT,IMAT和SMA的显著增加 (p<0.001).
- 骨肌密度 (SMD) 显著下降,从41 HU降至35.27 HU (p<0.001).
- 欧元网协议和霍奇金淋巴瘤与SAT和VAT的较大增加有关.
结论:
- 化疗显著改变了儿童淋巴瘤患者的身体组成.
- 脂肪组织 (SAT,VAT) 显著增加,而肌肉密度在治疗后减少.
- 特定的化疗方案 (EURONET) 和诊断 (霍奇金淋巴瘤) 与明显的脂肪组织积累有关.
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