过度活跃的膀激光治疗的相关标记:氧化和尿道神经生长因子
Rasha Ahmed1, Omnia Hamdy2, Mona Mohamed Abdulwehab3
1Urology Department, Faculty of Medicine for Girls, Al Azhar University, Cairo, Egypt.
Lasers in medical science
|February 6, 2025
概括
低水平激光疗法 (LLLT) 有效治疗过度活动的膀 (OAB). 氧化 (NO) 和尿道神经生长因子 (NGF) 显示出作为生物标志物的潜力,以跟踪接受LLLT的OAB患者的治疗成功.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物医学工程 生物医学工程
- 激光医学是激光医学.
背景情况:
- 过度活跃的膀 (OAB) 显著影响生活质量.
- 目前的OAB治疗有局限性,需要新的治疗方法.
- 确定治疗反应的可靠生物标志物对于个性化OAB管理至关重要.
研究的目的:
- 为了评估低水平激光疗法 (LLLT) 对过度活跃的膀 (OAB).
- 评估氧化 (NO) 和尿道神经生长因子 (NGF) 作为在接受LLLT的OAB患者治疗结果的潜在生物标志物.
主要方法:
- 一项前性随机对照试验,涉及50名OAB患者.
- 650nm激光照射 (LLLT) 的应用.
- 在干预前和后测量尿中NO和NGF水平.
主要成果:
- 在管理OAB症状方面,LLLT表现出有效性.
- 在LLLT后观察到NO和尿NGF水平的显著变化.
- 这些变化表明NO和NGF可以作为治疗反应的指标.
结论:
- LLLT是OAB的一种有前途的治疗方法.
- 尿中的NO和NGF水平显示出在OAB中LLLT疗效的预测生物标志物的潜力.
- 这些生物标志物可能有助于优化OAB治疗策略和个性化.
更多相关视频
10:26Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
Published on: August 18, 2014
26.2K
06:36A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
Published on: November 28, 2019
7.1K
相关概念视频
Nitric Oxide Signaling Pathway
4.9K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
4.9K
Antihypertensive Drugs: Vasodilators
463
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
463
