在阿尔茨海默氏病的频谱障碍中,大脑 - 丘脑 - 皮质回路的超连接性和连接体梯度功能障碍
Chenyang Yao1,2,3, Yi Shan1,2,3, Bixiao Cui1,2,3
1Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University, Beijing, China.
阿尔茨海默氏病 (AD) 和轻度认知障碍 (MCI) 显示大脑 - 丘脑 - 皮层 (CTC) 超连接性增加. 梯度分析揭示了干扰,表明了早期检测和AD治疗点的潜在生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 老年学是一门学科.
背景情况:
- 在阿尔茨海默氏病 (AD) 中观察到小脑功能连接的改变.
- 需要一个全面的框架,整合这些大脑 - 丘脑 - 皮质 (CTC) 电路在AD的发现.
- 功能梯度分析提供了一种阐明缺陷和识别潜在生物标志物的方法.
研究的目的:
- 为了研究大脑 - thalamo - 皮质 (CTC) 电路功能连接和在阿尔茨海默病 (AD) 的梯度变化.
- 通过功能梯度分析识别AD和轻度认知障碍 (MCI) 的潜在神经影像生物标志物.
- 探索CTC连接,认知功能和疾病进展之间的关系.
主要方法:
- 来自阿尔茨海默氏病神经成像计划 (ADNI-3) 的246名参与者的功能性MRI数据 (AD,MCI,认知正常对照) 的回顾性分析.
- 在CTC电路内对对的功能连接的计算和thalamic和小脑连接梯度的推导.
- 统计分析包括ANCOVA,Lasso回归用于分类,以及Pearson相关性来评估群体差异,确定歧视边缘,并探索认知关系.
主要成果:
- 与对照组相比,患有AD和MCI的个体表现出明显增加的CTC超连接性.
- 拉索回归确定了20个有区别的CTC边缘,在对AD和CN的分类中实现了高准确度.
- thalamic和小脑梯度分布在各组之间有显著差异,表明AD的广泛破坏,五个小脑网络显示梯度得分下降.
结论:
- 在AD和MCI中显著的CTC超连接性表明早期的thalamic和小脑调节障碍.
- 功能梯度分析揭示了全球和子领域层面的干扰,突出了状脑-小脑相互作用在认知衰退中的作用.
- 这些发现为阿尔茨海默病提供了潜在的诊断标志物和治疗点.
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