在怀孕期间失调的途径预测神经发育障碍中的药物候选者
Huamin Yin1,2, Zhendong Wang3, Wenhang Wang2
1Central Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Neuroscience bulletin
|February 6, 2025
概括
这项研究引入了一个新的框架来预测孕妇安全的候选药物,确定了19种与疾病相关的药物和256种用于神经发育障碍 (NDD) 的候选药物. 这些发现有助于在怀孕期间发现更安全的药物.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 遗传学 遗传学 是一个
背景情况:
- 怀孕期间母亲的健康和药物暴露显著影响后代的神经发育障碍 (NDD).
- 在怀孕期间评估药物风险是具有挑战性的,因为道德和实际限制.
- 现有的方法缺乏全面的框架来预测药物安全性和药物在胎儿发育中的疗效.
研究的目的:
- 开发和验证用于预测影响胎儿大脑发育和NDD的候选药物的分析框架.
- 确定针对NDDs风险路径的特定药物和类药物.
- 在NDDs的背景下分析性别偏见的药物通路相互作用.
主要方法:
- 精选的子路径和药物信息,以构建一个预测分析框架.
- 使用基因转录数据链接子/途径活性和药物反应得分.
- 应用,物流回归和随机森林模型来识别候选药物和分析性别偏见.
主要成果:
- 确定了19种与疾病相关的药物和256种针对NDD风险子/途径的区域性类药物/特定候选药物.
- 在胎儿发育过程中检测到药物向途径的时间和空间变化.
- 发现了5443种差异性药物子路径与性别偏差差异.
结论:
- 开发的框架有效地预测了NDD的候选药物,克服了怀孕药物安全性的数据缺口.
- 确定了许多针对六种NDD和胎儿发育的特定和类药物候选药物.
- 该框架为怀孕期间的药物发现提供了有价值的工具,并且可以适应其他特征.
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