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Updated: May 29, 2025

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在真菌细菌中通过核糖体分裂和rRNA破坏产生HflX介导的耐药性

Soneya Majumdar1, Amuliya Kashyap2, Ravi K Koripella1

  • 1Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12237.

Proceedings of the National Academy of Sciences of the United States of America
|February 6, 2025
PubMed
概括

菌根菌的HflX蛋白分裂了抗生素停滞的核糖体,产生不活跃的子单元,从而赋予抗生素耐药性. 这种独特的机制涉及独特的N端延伸和插入,甚至与结合的抗生素相互作用.

关键词:
50S子单元的无活化抗生素耐药性 抗生素耐药性低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.菌根菌 HflXX 的情况.细菌核糖体-HflX复合物的结构.

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