概括
与饮食一起服用补充剂可显著改善尿路参数,防止酸氧化结石,而不是在禁食期间服用它们. 这种饮食时间增强了石头预防策略.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养生物化学 营养生物化学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 尿中的对于防止氧化酸结石形成至关重要.
- 补充的最佳时间尚不清楚.
研究的目的:
- 为了研究补充时间 (与餐饮相比禁食) 对容易发生氧酸盐结石的患者尿路生物化学的影响.
主要方法:
- 一项前性,随机控制的试点研究,涉及有氧酸结石史和孤立高氧沙uria的患者.
- 患者接受了受控饮食,并随机分配在7天内与餐或禁食期间服用补充剂.
- 在干预前和后进行了24小时尿液分析.
主要成果:
- 与饮食一起服用的患者表现出更大的改善:尿中氧酸盐 (17.8 mg/d) 的中位数下降,尿中的增加 (33.6 mg/d) 和尿中酸盐的增加 (134.8 mg/d).
- 禁食期间服用的患者有较小的改善:尿液中氧酸盐的平均下降 (8.5 mg/d),尿液中的增加 (21.8 mg/d) 和尿液中酸盐的增加 (116.6 mg/d).
结论:
- 摄入与饮食一起的补充剂会导致尿路参数的更实质性的改善,这与预防酸结石有关.
- 对于患有复发性氧化酸腎石病的患者,建议在餐时服用补充剂.
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