父母缓解酒精使用障碍和后代酒精使用启动,AUD和缓解高风险家庭样本中的缓解
Vivia V McCutcheon1, Sally I-Chun Kuo2, Rebecca L Smith3
1Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Journal of studies on alcohol and drugs
|February 6, 2025
概括
父母酒精使用障碍 (AUD) 缓解为后代提供了混合的结果. 缓解可能会增加后代AUD风险在欧洲裔美国人,但与早期饮酒在非洲裔美国人,显示复杂的遗传和社会影响.
科学领域:
- 遗传学和行为学
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 父母饮酒障碍 (AUD) 是后代精神病理的一个重要风险因素.
- 了解父母AUD缓解对后代结果的影响对于预防和干预策略至关重要.
- 遗传和社会文化因素可能会影响AUD的代际传播.
研究的目的:
- 为了研究父母AUD缓解如何影响后代的酒精使用轨迹.
- 根据大陆祖先 (欧洲裔美国人与非洲裔美国人) 检查这些协会的差异.
- 探索父母AUD状态和缓解后代第一次饮酒时的年龄,AUD发作和缓解中的作用.
主要方法:
- 利用了来自"饮酒遗传学合作研究" (COGA) 的自我报告数据 (n=2244个后代).
- 采用时间变化的考克斯模型来评估父母AUD/缓解和后代结果之间的关联.
- 根据问题性酒精使用的多基因风险评分 (PGSPAU) 和欧洲裔美国人 (EA) 和非洲裔美国人 (AA) 祖先的分层分析进行调整.
主要成果:
- 在欧洲裔美国人 (EA) 中,母亲AUD缓解与后代AUD风险增加有关.
- 在非洲裔美国人 (AA) 中,父母AUD缓解与早期的后代饮酒有关,母亲缓解的影响因青少年的生活状况而异.
- 父亲AUD缓解,但不是母亲,在AA中增加后代AUD发病风险;父母身份在两个组中都没有预测后代缓解.
结论:
- 父母AUD缓解的证据显示,缓解后代风险的证据有限且混合,因祖先和性别而异.
- 这些发现强调了父母AUD状态,缓解和后代与酒精有关的行为之间的复杂相互作用.
- 社会文化因素和遗传倾向有助于酒精使用障碍的微妙的代际模式.
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