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Ananya A Basu1,2, Chenlu Zhang1, Milad Rouhimoghadam3

  • 1Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.

Journal of the American Chemical Society
|February 6, 2025
PubMed
概括

有针对性的蛋白质降解可以利用病细胞中发现的突变E3链酶. 这种方法通过劫持细胞机械来消除特定的致病蛋白来扩大治疗选择.

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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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