细菌性传染病暴露前预防的可接受性和可行性:系统性审查
Julie-Anne Carroll1, Amy B Mullens2, Sarah Warzywoda3,4
1School of Public Health and Social Work, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
PloS one
|February 6, 2025
概括
抗生素暴露前预防 (STI PrEP) 在与男性发生性关系的男性中显示出中度至高的可接受性,但抗菌素耐药性和耻辱感等问题构成了障碍. 为了更广泛的实施,需要进一步的研究.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 细菌性传播感染 (STIs) 正在复苏,增加了医疗保健系统和高风险人群的负担.
- 抗生素暴露前预防 (STI PrEP) 是一种潜在的干预措施,但其在风险群体中的可接受性和可行性尚未得到充分理解.
研究的目的:
- 在高风险人群中系统地审查有关STI PrEP可接受性和可行性的文献.
- 确定影响采用STI PrEP的因素,并突出未来研究领域.
主要方法:
- 在2024年10月,根据PRISMA指南,在六个数据库中进行了全面的文献搜索.
- 包括的研究集中在各种高风险人群中STI PrEP的可接受性和可行性.
主要成果:
- 八项研究符合纳入标准,所有研究都在高收入国家进行,重点关注同性恋,双性恋和其他与男性发生性关系的男性 (GBMSM).
- 在GBMSM中,接受度从54.3%到67.5%不等,受感知风险和先前的性传播疾病诊断的影响,但受到对抗菌素耐药性和耻辱感的担忧的阻碍.
- 有限的数据存在于医疗保健工作者愿意开处方STI PrEP和GBMSM以外的人口的观点.
结论:
- STI PrEP在GBMSM中显示出有希望的可接受性,但在可行性,知识转移和可持续性方面仍然存在重大知识差距.
- 了解社会文化背景对不同人群中STI PrEP吸收的影响至关重要.
- 涉及各种高风险群体,医疗保健专业人员和政策制定者的进一步研究对于成功实施STI PrEP至关重要.
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