在早期类风湿关节炎中视网膜血管参数的变化 (通过光学一致性断层扫描血管造影):一项基于医院的研究
Amany M Ebaid1, Enas M Mekkawy1, Hala K Mattout2
1Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ocular immunology and inflammation
|February 6, 2025
概括
光学一致性断层扫描血管图 (OCTA) 显示,在早期类风湿性关节炎 (RA) 患者中,视网膜血管密度降低. 这些微循环变化与疾病活性和持续时间相关,这表明OCTA.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 医疗成像医学成像
背景情况:
- 类风湿性关节炎 (RA) 是一种全身性自身免疫性疾病.
- 早期的RA可以影响微循环,但检测方法有限.
研究的目的:
- 在早期的RA中使用OCTA评估视网膜血管变化.
- 为了将这些血管变化与RA疾病活动相关联.
主要方法:
- 在54名早期RA患者和33名健康对照组中进行了光学一致性断层扫描血管图 (OCTA).
- 评估了表面 (SCP) 和深视网膜毛细血管 (DCP),状血管区域 (FAZ) 和辐射周毛细血管 (RPC) 的血管密度 (VD).
- 与风湿学检查和疾病活性得分 (DAS28) 相关联的OCTA发现.
主要成果:
- 与对照人群相比,RA患者的RPC值显著降低,并改变了叶/周叶测量值.
- 在 RA 患者中,状血管区域 (FAZ) 显著增加.
- 在疾病持续时间/DAS28和RPC/foveal测量之间发现了负相关性;在抗CCP标位和FAZ之间发现了正相关性.
结论:
- 在RA患者中,OCTA可以检测早期的视网膜微循环障碍.
- 周,和准区域的血管密度降低表明早期的RA.
- OCTA显示出作为RA的诊断和监测工具的潜力.
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