来自Trichoderma harzianum的新型多基化物及其抗真菌活性
Chengzeng Zhou1, Jiayu Pan1, Yichao Ge1
1Ocean College, Zhejiang University, Zhoushan, China.
Chemistry & biodiversity
|February 6, 2025
概括
从Trichoderma harzianum ZN-4中鉴定出七种新的真菌化合物,harzianolides K-Q,这些真菌化合物是从Trichoderma harzianum ZN-4中发现的. 一些化合物表现出抗Pestalotiopsis theae活性,表明可能出现新的抗真菌剂.
科学领域:
- 海洋天然产品化学 海洋天然产品化学
- 的二次代谢产物 的二次代谢产物
- 发现抗微生物药物发现.
背景情况:
- 海洋衍生真菌是新型生物活性化合物的丰富来源.
- 三体物种是众所周知的各种二次代谢物的生产者.
- Pestalotiopsis theae是一种致病性植物真菌,造成了严重的农业损失.
研究的目的:
- 从海洋衍生真菌Trichoderma harzianum ZN-4中分离和描述新的二次代谢物.
- 评估分离化合物的生物活性,包括抗菌,抗瘤和抗真菌性质.
主要方法:
- 使用染色学技术进行化学研究.
- 通过高分辨率质谱 (HRMS) 和核磁共振 (NMR) 光谱学阐明结构.
- 电子循环二元化 (ECD) 计算用于绝对配置的确定.
- 生物活性测定:抗菌,抗瘤和抗Pestalotiopsis theae活性测试.
主要成果:
- 七种新的二次代谢物,被指定为harzianolides K-Q (1-7),被分离和结构阐明.
- 发现 1-7 化合物作为抗菌和抗瘤剂是无活性的.
- 哈尔齐阿诺利德K (1),L (2),M (3) 和O (5) 对Pestalotiopsis theae表现出弱至中度活性,最小抑制度 (MIC) 范围为25-100μg/mL.
结论:
- 海洋衍生的真菌Trichoderma harzianum ZN-4产生了一系列新的harzianolides.
- 哈尔齐阿诺利德K,L,M和O对Pestalotiopsis theae具有抗真菌活性,这表明它们有可能成为开发新抗真菌剂的头.
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