怀孕前蛋白质摄入量与妊娠糖尿病之间的关系:日本环境和儿童研究
Takahiro Omoto1, Hyo Kyozuka1, Tsuyoshi Murata1
1Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan; Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Diabetes & metabolic syndrome
|February 6, 2025
概括
更高的孕前蛋白质摄入量与早期诊断妊娠糖尿病 (GDM) 的风险增加有关. 较低摄入量显示风险降低,突出显示需要精细的饮食指导.
科学领域:
- 生殖健康 生殖健康
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 孕期糖尿病 (GDM) 对母亲和胎儿的健康构成风险.
- 最佳的孕前营养对于妊娠的结果至关重要.
- 了解宏观营养素摄入量,特别是蛋白质的作用至关重要.
研究的目的:
- 检查怀孕前蛋白质摄入量与发展GDM的风险之间的关联.
- 为了区分早期诊断的GDM (Ed-GDM) 与晚期诊断的GDM (Ld-GDM) 的风险.
主要方法:
- 分析了来自日本环境和儿童研究的80,346名参与者的数据.
- 根据预先概念的蛋白质能量比率将参与者分为五分之一的分类.
- 后勤回归分析用于计算GDM,Ed-GDM和Ld-GDM的调整赔率比率.
主要成果:
- 更高的孕前蛋白摄入量 (Q5) 与ED-GDM风险增加有关 (aOR 1.48).
- 较低的孕前蛋白摄入量 (Q1) 与ED-GDM风险降低有关 (aOR 0.69).
- 在蛋白质摄入量和整体GDM或Ld-GDM风险之间没有发现显著的关联.
结论:
- 孕前蛋白质摄入量增加可能会增加早期发生GDM的风险.
- 关于怀孕前蛋白质摄入的饮食建议需要进一步调查和细化.
- 这项研究强调了孕前饮食在GDM风险分层中的重要性.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
Pathophysiology of Diabetes
852
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
852
Nature and Nurture
20.4K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.4K
Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
Overview of Protein Metabolism
696
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
696
Teratogenicity
2.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K


