在产母中测量下丘脑-垂体-上腺轴激活的年龄影响
Meagan E Abraham1, Priscila Serpa2, Gregory S Fraley1
1Department of Animal Sciences, Purdue University, West Lafayette, Indiana 47907-2050 USA.
Poultry science
|February 6, 2025
概括
在研究家禽的压力时,这项研究发现血皮质可用于测量幼和成年母的下丘脑-垂体-上腺轴激活. 然而,异形细胞:淋巴细胞比率和血皮质醇是急性压力的不太可靠指标.
科学领域:
- 兽医科学 兽医科学 兽医科学
- 动物生理学 动物生理学
- 鸟类生物学 鸟类生物学
背景情况:
- 商业家禽的压力反应是复杂的,并未完全理解.
- 脑下垂体 - 脑下垂体 - 上腺 (HPA) 轴的激活,通常通过葡萄糖皮质激素水平测量,是鸟类压力的常见指标.
- 禽类的生理成熟和生产阶段可能会影响HPA轴反应.
研究的目的:
- 为了评估不同生理年龄 (6,17,26周岁) 的Lohmann LSL-Lite中HPA轴激活的变化.
- 评估血皮质,血皮质醇和异形细胞:淋巴细胞 (H:L) 比率作为急性HPA激活的指标的可靠性.
- 为了确定卵白蛋白,皮质和皮质醇作为HPA激活生物标志物的有用性.
主要方法:
- 在6周,17周和26周的年龄接受了盐酸曼尼托尔 (对照) 或上皮质激素 (ACTH1-24) 的注射.
- 在注射前和注射后1个和2个小时收集血液样本进行分析.
- 血皮质和皮质醇使用HPLC-MS/MS测量;白细胞分数用于计算H:L比率. 卵膜也在26周时进行了分析.
主要成果:
- 血皮质水平在ACTH注射后1小时增加,在17周大时显著增加.
- ACTH治疗没有显著影响H:L比率,尽管异质细胞增加,淋巴细胞在26周减少.
- 血皮质醇和卵皮质/皮质醇并不是所有测试年龄段急性HPA激活的可靠指标.
结论:
- 的H:L比率不是在母幼阶段急性HPA激活的准确衡量标准.
- 血皮质醇和卵白皮质/皮质醇不是在幼或成年阶段急性HPA激活的可靠指标.
- 血皮质显示出评估幼和成年母生理应激反应的潜力,需要进一步调查.
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