多omics阐明了水中Cu通过子的肠轴引起的脏损伤
Mingcai Duan1, Jinyu Liu2, Zhaoxia Cai3
1Key Laboratory of Livestock and Poultry Resources (Poultry) Evaluation and Utilization, Ministry of Agriculture and Rural Affairs of China, Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China; Hubei Hongshan Laboratory, National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Ecotoxicology and environmental safety
|February 6, 2025
概括
在子中过度接触铜会通过破坏肠道微生物群和改变代谢物,突出肠-轴的毒性而导致脏损伤. 这项研究揭示了水禽中铜诱导的炎和肠道失生症.
科学领域:
- 环境毒理学环境毒理学
- 微生物学 微生物学
- 脏生理学 脏生理学
背景情况:
- 铜 (Cu) 是必需的,但在高剂量时是有毒的.
- 过多的对通过肠道微生物群对功能的影响尚不清楚.
- 在水生环境中容易受到Cu污染.
研究的目的:
- 为了研究Cu暴露对子脏炎症的影响.
- 为了阐明肠-轴在Cu诱导的损伤中的作用.
- 为了确定与Cu毒性相关的微生物和代谢变化.
主要方法:
- 在4周的时间里,子接受了不同剂量的硫酸铜 (CuSO4) 输入.
- 测量了和血清炎症标志物 (TNFα,IL-6,IL-1β).
- 分析了肠道微生物组组成 (16S rDNA),脏基因表达 (转录组学) 和代谢物概况 (代谢组学).
主要成果:
- 暴露于Cu导致脏病理损伤和炎症标志物增加.
- 观察到肠道微生物群的显著变化,包括减少了Bacteroides和Candidatus_Saccharimonas.
- 鉴定了脏组织中的基因表达差异和脏和骨中的代谢物变异概况,与炎症和肠道微生物有关.
结论:
- 过多的摄入会导致子的炎症和损伤.
- 肠-轴在调解Cu毒性的过程中起着至关重要的作用.
- 肠道微生物群的破坏和相关的代谢变化有助于Cu诱导的功能障碍.
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