优化pyrazole/1,2,4-triazole作为EGFR/COX-2双抑制剂:设计,合成,抗癌潜力,亡诱导和细胞周期分析

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Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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Published on: June 23, 2019

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Nesma M Kahk1, Fatma E A Mohamed1, Marwa M Abdelhakeem1

  • 1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni- Suef, 62514, Egypt.

European journal of medicinal chemistry
|February 6, 2025
PubMed
概括

新型pyrazol-4-yl-1,2,4-triazole-3-thiol衍生物对乳腺,结肠和肺癌细胞系表现出显著的抗增殖活性. 最强效的化合物有效抑制COX-2和EGFR酶,诱导细胞亡和细胞循环停止.

关键词:
1,2,4 三醇的使用情况COX-2 抑制剂的使用细胞周期分析分析欧洲农业基金 (EGFRT) (790M)皮拉 (Pyrazole) 是一种可怕的药物.

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