对主观认知衰退个体的客观和自我报告认知功能的纵向分析
Seon Young Ryu1, Chunghwee Lee2, SeongHee Ho2
1Department of Neurology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, streamline@catholic.ac.kr.
在主观认知衰退的个体中,微妙的认知障碍预测了更快的客观认知衰退和更多的阿尔茨海默病生物标志物. 只有自我报告的投诉对监测变化不那么有效.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 主观认知衰退 (SCD) 是临床前阿尔茨海默病 (AD) 的早期指标.
- 在SCD中微妙的认知障碍 (SCI) 与临床衰退的风险增加有关.
- 了解SCD的纵向认知变化对于早期AD检测至关重要.
研究的目的:
- 研究SCD患者的纵向认知轨迹.
- 检查微妙认知障碍 (SCI) 对认知功能和AD生物标志物的影响.
- 为了比较有或没有SCI的SCD中的客观和自我报告的认知变化.
主要方法:
- 107名SCD患者接受了年度认知评估和神经成像.
- 分析了中间叶体积和AD生物标志物 (粉样蛋白,蛋白).
- SCD参与者被分为SCI (n=22) 和非SCI (n=85) 组.
主要成果:
- 患有SCI的SCD个体比没有SCI的人更快地表现出客观认知衰退.
- 脑损伤组显示脑内皮层体积减少和缩加速.
- SCI组的AD生物标志物异常显著多,包括粉样蛋白和p-tau181.1.
结论:
- 在SCD中SCI状态是认知衰退和AD病理学的重要预测因素.
- 早期识别SCI可能会提高预测在临床前AD认知能力下降.
- 自我报告的认知投诉在监测SCD的临床变化方面具有有限的效用.
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