d-β-hydroxybutyrate对健康参与者的睡眠质量的影响:一项随机,双盲,安慰剂控制的随机研究
Shohei Katsuya1, Yoshikazu Kawata1, Yosuke Kawamura1
1Energy Technology Laboratories, Osaka Gas Co., Ltd., Konohana-ku, Osaka, Japan.
Bioscience, biotechnology, and biochemistry
|February 6, 2025
概括
在健康的日本成年人中,d-β-酸 (D-BHB) 补充改善了睡眠质量. 与安慰剂相比,服用D-BHB的参与者报告说,嗜睡减少,睡眠开始,维持和刷新更好.
科学领域:
- 营养神经科学 营养神经科学
- 睡眠医学 睡眠医学
- 代谢健康 代谢健康
背景情况:
- 睡眠质量对整体健康和福祉至关重要.
- 体,如d-β-基酸 (D-BHB),越来越多地研究它们的潜在生理作用.
- D-BHB对健康成年人睡眠参数的影响需要进一步研究.
研究的目的:
- 评估d-β-酸 (D-BHB) 补充剂对健康日本成年人睡眠质量的疗效.
- 为了比较低剂量和高剂量D-BHB与安慰剂的影响.
主要方法:
- 这是一项为期14天的随机,安慰剂控制,双盲,并行组研究.
- 参与了90名健康的日本成年人,分为三个组:安慰剂,低D-BHB (1.5g) 和高D-BHB (2.9g).
- 使用Oguri-Shirakawa-Azumi睡眠清单 (OSA-MA) 和干预前后睡眠状态测试来评估睡眠质量.
主要成果:
- 与安慰剂相比,低D-BHB和高D-BHB组在"起床时昏昏欲睡"和"经常做梦"方面的OSA-MA得分显著更高.
- 低D-BHB组在"启动和维持睡眠"方面显著改善.
- 高D-BHB组在"升高时清爽"分数显著增加.
结论:
- 补充d-β-酸 (D-BHB) 可以提高健康的日本成年人的睡眠质量.
- D-BHB可能有助于减少早晨的嗜睡,改善睡眠的开始,维持和恢复.
- 这些发现表明D-BHB是改善睡眠的潜在营养干预措施.
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